Calpain 3 Is Activated through Autolysis within the Active Site and Lyses Sarcomeric and Sarcolemmal Components
نویسندگان
چکیده
منابع مشابه
Calpain-3 is activated following eccentric exercise.
TO THE EDITOR: In a recent article by Lehti et al. (3) the effect of fatiguing exercise on the mRNA expression of a number of skeletal muscle proteins was examined. In the discussion it was stated that in a study conducted by our laboratory, calpain-3 mRNA was increased 24 h after a bout of eccentric exercise (4). It needs to be pointed out that this was NOT a finding in that manuscript and the...
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The role of autolysis in activity of the Ca2+-dependent proteinases (mu-calpain and m-calpain).
A recent hypothesis suggests that proteolytic activity of the micromolar and millimolar Ca2+-requiring forms of the Ca2+-dependent proteinases (mu- and m-calpain, respectively) is regulated in vivo by their association with a phosphatidylinositol-containing site on the plasma membrane followed by autolysis of the proteinases. Phosphatidylinositol association lowers the Ca2+ concentration needed...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2003
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.23.24.9127-9135.2003